David Leonardi, M.D. ABAAM, CNS

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Vitamin D Supplementation as a Possible Solution to Statin-Related Muscle Pain

David Leonardi, M.D., ABAAM, CNS

Bullet Points

  • If you have statin-related muscle pain or weakness and your blood level of vitamin D is low (less than 32 ng/ml), there is a good chance that vitamin D repletion will solve your problem.
  • If your vitamin D level is not low (above 32 ng/ml), taking extra vitamin D will probably not help.  You should focus on buffered creatine and CoQ10.
  • Statin Sidekick™ contains all three: Vitamin D3, buffered creatine and CoQ10 in a proprietary ratio to take the guesswork out of the equation. Whichever ingredient or combination of ingredients you require, you’re covered.


Very low levels of vitamin D (even in the absence of statin use) are associated with muscle dysfunction and muscle pain1,2,31,2,3. Low levels of vitamin D are common throughout the world, including in developed countries and certainly including the U.S.4,5,6. Based on the published literature and my own practice experience over the past ten years, I estimate that half of all Americans have vitamin D levels in the insufficient range, defined as less than 32 ng/ml4,5,6. There are studies showing a correlation between low vitamin D levels and statin-associated muscle pain7,8 and others showing no such association9,10. Therefore, low vitamin D cannot possibly be the simple answer to statin-associated muscle problems for everyone. However, if your vitamin D level is low, replenishing your vitamin D stores might well relieve your muscle pain. Here’s why:  In two studies of people with statin-associated muscle pain and a low level of vitamin D, when the statin was temporarily stopped and the level of vitamin D was boosted above 32 ng/ml, most were able to restart their statin with no pain11,12. Therefore, a low vitamin D status may be the cause of statin-associated muscle pain in some people and vitamin D repletion, therefore, may be helpful. That’s why we include vitamin D3 in every order of Statin Sidekick™. We want you to be successful in stopping muscle pain, weakness, tremors or soreness in their tracks and enjoy the cardiovascular protection that statins can offer without side effects. With Statin Sidekick, whether it’s the vitamin D3, the Coenzyme Q10 or the buffered creatine that is helping doesn’t matter because all three are present in Statin Sidekick.

The Safest, Most Economical and Simplest Solution

As a result of the overwhelming benefits of both CoQ10 and buffered creatine we’ve discussed, along with the benefit of vitamin D3 in those with insufficient levels, I decided to combine CoQ10, buffered creatine and vitamin D3 into one convenient nutritional supplement called Statin Sidekick™.  I believe Statin Sidekick is critically important for anyone taking a statin medication along with anyone physically active and interested in insuring a steady supply of energy to muscle and brain cells. Two capsules of Statin Sidekick provides a proprietary blend of buffered creatine and CoQ10 totaling 1,500 mg. along with 2,000 iu of vitamin D3. These three ingredients are included in the most optimal ratio based on published clinical trials, our original research and our patient experience at the Leonardi Institute. The recommended dose is 2 to 3 capsules of Statin Sidekick twice a day (always with food) for the first week (called a “loading dose”) followed by 1 to 2 capsules twice a day thereafter.  There appears to be an advantage to stopping your statin for the first week while taking the loading dose of Statin Sidekick, but we don’t recommend doing this without first checking with your practitioner.  If you notice muscle aching that you feel is related to your statin while taking Statin Sidekick™, simply increase the dose back up to 3 capsules twice a day. Of course, you should also notify your physician that your statin is causing you pain. You may adjust the dose of Statin Sidekick up and down to see what dose you personally require to eliminate statin-related muscle aching while optimizing muscle energy availability and performance. In unusual circumstances, a few people may even require 4 capsules twice a day. Detailed dosing instructions are included with each order. If 4 capsules of Statin Sidekick twice daily doesn’t relieve your statin side effects, the next logical step might  be to discuss with your practitioner, either an alternative statin or a lower dose of the same statin while continuing Statin Sidekick. If you’re unsuccessful with that approach you may want to discuss statin alternatives with your practitioner.

Statin Sidekick is an essential nutrient for anyone taking a statin. It provides that margin of safety and peace of mind that you’re getting the best possible performance from your muscles while reducing the risk of muscle pain and muscle dysfunction that can accompany statin use. If you would like to order Statin Sidekick, it is available on our Cycle-Breakers.com website by clicking here. Statin Sidekick is carefully tested and manufactured in full compliance of U.S. government Good Manufacturing Processes (GMP).

Statin Sidekick Supplement Facts

Serving size 2 capsules

Servings per Container 30 (60 capsules)

Active Ingredients
Amount per Serving
Vitamin D32,000 iu500
A proprietary blend of Kre-Alkalyn® (buffered creatine) and Coenzyme Q101500 mgDRV not established

Directions: Take 2-3 capsules twice daily WITH FOOD (within 45 minutes of a meal). You may reduce the dose after the first week if you remain free of statin side effects, or increase the dose if needed.


1 1Boland R. Role of vitamin D in skeletal muscle function. Endocr Rev 1986; 7:434-48.

2 2Holick MF. Vitamin D Deficiency. N Engl J Med 2007; 357:266-81.

333Ceglia L. Vitamin D and skeletal muscle tissue and function. Mol Aspects Med 2008; 29:407-14.

44Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med 2002; 112:659-62.

5 5Calvo MS, Whiting SJ. Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use. Nutr Rev 2003; 61:107- 13.

6 6Calvo MS, Whiting SJ, Barton CN. Vitamin D intake: a global perspective of current status. J Nutr 2005; 135:310-6.

7 7Duell PB, Connor WE. Vitamin D deficiency is associated with myalgias in hyperlipidemic subjects taking statins. Circulation 2008; 118:470.

88Ahmed W, Khan N, Glueck CJ, Pandey S, Wang P, Goldenberg N, et al. Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myo- sitis-myalgia in statin-treated patients. Translational Research 2009; 153:11-6.

99Riphagen IJvan der Veer EMuskiet FADeJongste MJ.Curr Med Res Opin.Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic: prevalence, predictors and relation with vitamin D. 2012 Jul;28(7):1247-52. doi: 10.1185/03007995.2012.702102. Epub 2012 Jun 28.

1010Kurnik DHochman IVesterman-Landes JKenig TKatzir ILomnicky YHalkin HLoebstein R. Clin Endocrinol (Oxf). Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins.2012 Jul;77(1):36-41. doi: 10.1111/j.1365-2265.2011.04321.x.

1111Linde RPeng LDesai MFeldman D. The role of vitamin D and SLCO1B1*5 gene polymorphism in statin-associated myalgias. Dermatoendocrinol. 2010 Apr;2(2):77-84. doi: 10.4161/derm.2.2.13509.

1212Ahmed WKhan NGlueck CJPandey SWang PGoldenberg NUppal MKhanal S. Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl Res. 2009 Jan;153(1):11-6. doi: 10.1016/j.trsl.2008.11.002. Epub 2008 Dec 6.

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